Affinity DataIC50: 36nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 80nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 90nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 100nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 200nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 240nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
Affinity DataIC50: 255nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 400nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
Affinity DataIC50: 473nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 500nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
Affinity DataIC50: 671nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 700nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
Affinity DataIC50: 733nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 765nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 785nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 850nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
Affinity DataIC50: 907nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.00E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.09E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
Affinity DataIC50: 1.39E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.40E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.50E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
Affinity DataIC50: 1.72E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
Affinity DataIC50: 1.97E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 2.00E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 2.09E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
Affinity DataIC50: 2.46E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 3.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 3.08E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
Affinity DataIC50: 3.62E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 3.68E+3nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
Affinity DataIC50: 4.75E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 4.90E+3nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
Affinity DataIC50: 5.35E+3nMpH: 6.8Assay Description:Briefly, 1,3,4-thiadiazole derivatives were tested for diphenolase inhibitory activity of tyrosinase using L-DOPA (dihydroxyphenylalanine) as substra...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 6.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 6.40E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 7.30E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 8.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 8.00E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 8.50E+3nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 8.80E+3nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.01E+4nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L](Agaricus bisporus (Mushroom))
University of Technology Sydney
University of Technology Sydney
Affinity DataKi: 3.80E+3nM IC50: 1.04E+4nMpH: 6.8Assay Description:The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.05E+4nMpH: 6.8 T: 2°CAssay Description:In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.10E+4nMAssay Description:A tyrosinase inhibition assay was carried out using the method reported by Jones et al. (2002) Pigment. Cell Res. 15:335. Using this method, the conv...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.18E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L](Agaricus bisporus (Mushroom))
University of Technology Sydney
University of Technology Sydney
Affinity DataKi: 4.50E+3nM IC50: 1.44E+4nMpH: 6.8Assay Description:The mushroom tyrosinase inhibition activity of hydroxy naphthylchalcone compounds was measured using L-DOPA as substrate. The activity assay used 3 m...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.48E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.50E+4nMpH: 6.8Assay Description:Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...More data for this Ligand-Target Pair
TargetPolyphenol oxidase 1(Agaricus bisporus (White button mushroom))
Pierre Fabre Dermo-Cosmetique
US Patent
Pierre Fabre Dermo-Cosmetique
US Patent
Affinity DataIC50: 1.67E+4nMpH: 6.8 T: 2°CAssay Description:Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...More data for this Ligand-Target Pair